Research First !

Thank you for visiting the website of our department.

The Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University is working to analyze

the molecular pathogenesis of infectious diseases and cancer from a new perspective based on sulfur metabolism,

as well as to develop new treatments for these diseases.

What's New?

  • 2025/03/29 [Publications] A paper of Prof. Yamagata et al. of the Department of Medical Biochemistry has been published in Int. J. Mol. Sci.  From our Lab, Assistant Professor Ono, Dr. Zhang (now at Akita Univ.) and Prof. Sawa joined as co-authors. Congratulations! <link>
  • 2025/03/28 [Graduation] The graduation ceremony for the academic year of 2024 was held on March 25. <link>
  • 2025/02/18 [Publications] Dr. Zhang's (now at Akita Univ.) review article was published in Microbiol Immunol. <link>
  • 2025/01/28 [Publications] A paper first authored by Mr. Azizur Rahman, Technical Assistant, has been published in Int. J. Mol. Sci. <link>
  • 2024/10/29 [Award] Ms. Guo, a graduate student, received the Young Investigator Award at The 11th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia 2024) held in Beijing on October 21-23, 2024. <link>
  • 2024/10/04 [Admission] We are pleased to announce that Ms. Jahan Nusrat has enrolled as a master's student on October 1 (fall enrollment). <link>
  • 2024/09/27 [Degree Conferral] Ms. Li Xiaoyan, a graduate student in the working course, received her degree. <link>
  • 2024/09/21 [Award] Ms. Ayaka Uegama, a graduate student, received the Best Poster Presentation Award at the Kyushu Microbial Research Forum 2024. <link>
  • 2024/09/16 [Award] Dr. Zhang (currently Assistant Professor at Akita University) received the Best Poster Presentation Award at the 35th Annual Meeting of the Japanese Society for Host Defense Research. <link>
  • 2024/09/08 [Internship] Mr. Hanyu Liu, an internship student from China, has successfully completed the program. <link>
  • 2024/09/04 [Publications] Virus Team's Paper Accepted by J Biol. Chem. This is the work of graduate student Nyame and Prof. Monde et al. <link>
We're looking for graduate students to work with us on our research!
Please feel free to contact us anytime if you are interested. Please refer to the link (in Japanese) for the entrance examination for the 2025 academic year. <link>

History

The origin of medical education in Kumamoto is said to be the "Saishunkan Medical Dormitory" established by Shigeken Hosokawa, the lord of the Higo domain, in 1756. Furthermore, Shibasaburo Kitasato, who is known as the father of bacteriology in Japan, studied under a Dutch doctor, Dr. Mansfeldt, as a medical student at the "Kojo Medical School" established by the Kumamoto domain in 1870.

The Department of Microbiology was established in 1907, shortly after the private Kumamoto Medical School, the predecessor of Kumamoto University School of Medicine, was approved as a medical school.

Since the inauguration of the first Professor Hidekazu Nakajima, the following professors have been appointed: the 2nd Professor Toyokichi Ohtahara (Kumamoto Medical College), the 3rd Professor Tokichi Rokutanda (National Kumamoto University School of Medicine), the 4th Professor Yorio Hinuma (National Kumamoto University School of Medicine), the 5th Professor Hiroshi Maeda (moved to National University Corporation), the 6th Professor Takaaki Akaike (Kumamoto University Graduate School of Medicine and Pharmaceutical Sciences, Department of Microbiology; currently Tohoku University), and the current Professor Tomoaki Sawa (Department of Microbiology, Kumamoto University Graduate School of Life Sciences), have taken over the Department of Microbiology and have a history of more than 100 years.

Our department has produced many researchers and educators who have led the field of infectious diseases not only in Japan but also in the world.

Inheriting this illustrious tradition, since 2014, under the leadership of Professor Tomohiro Sawa, we have been conducting research on the molecular pathogenesis of infectious diseases, immunity, and cancer from the new perspective of sulfur metabolism, while at the same time providing undergraduate and graduate education for the development of outstanding human resources.

Research

In our laboratory, we are conducting basic research to understand the mechanisms of infectious diseases caused by bacteria and viruses at the molecular level, and to obtain knowledge that can be applied to effective prevention, diagnosis, and treatment. In particular, we are studying the stress response mechanisms of pathogens and host cells in the field of infection using the latest analytical techniques. We are currently working on the following research projects.

 

I. Elucidation of Sulfur Metabolism and Antioxidant Defense Mechanism in Bacteria

II. Novel Metallo-β-Lactamase Inhibitors

III. Analysis of The Mechanism of Action of Enterohemorrhagic Escherichia Coli Toxin (SubAB)

IV. Regulation of Innate Inflammation and Infectious Immunity by Reactive Sulfur Species.

Ⅴ.    Elucidation of The Antiviral Effects of Reactive Sulfur Species

VI.   Analysis of the intracellular invasion mechanism of human immunodeficiency virus (HIV-1)

VII. Elucidation of the mechanism of HIV-1 acquisition of drug resistance.

VIII. Effects of Human Endogenous Viruses (HERVs) and HIV-1 on Infection and Replication

Ⅸ. Analysis of the interaction between envelope proteins and receptors of human T-cell leukemia virus (HTLV-1).

Ⅹ. Research on Polymeric Anticancer Agents

Ⅺ.Research on The Spread of Drug-Resistant Bacteria and Its Prevention

VI~IX are projects in Virus Research Section.

Please also see our research projects site.

Recent Publications

  • Kibria, M.G., Yoshizawa, T., Zhang, T., Ono, K., Mizumoto, T., Sato, Y., Sawa, T., Yamagata, K. SIRT7 Is a Lysine Deacylase with a Preference for Depropionylation and Demyristoylation. Int. J. Mol. Sci. 2025, 26, 3153. https://doi.org/10.3390/ijms26073153.
  • Zhang, T., Toyomoto, T., Sawa, T., Akaike, T., Matsunaga, T., Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases. Microbiology and Immunology, First published: 16 February 2025 https://doi.org/10.1111/1348-0421.13205.
  • Rahman, A., Ono, K., Toyomoto, T., Hanaoka, K., Sawa, T., Identification of Fungal Metabolite Gliotoxin as a Potent Inhibitor Against Bacterial O-Acetylserine Sulfhydrylase CysK and CysM.  Int. J. Mol. Sci. 2025, 26(3), 1106; https://doi.org/10.3390/ijms26031106.  
  • Perpetual Nyame, P., Togami, A., Yoshida, T., Masunaga, T., Begum, M.M., Terasawa, H., Monde, N., Tahara, Y., Tanaka, R., Tanaka, Y., Appiah-Kubi, J., Amesimeku, W.O., Hossain, M.J., Otsuka, M., Yoshimura, K., Ikeda, T., Sawa, T., Satou, Y., Fujita, M., Maeda, Y., Tateishi, H., Monde, K., A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24. J Biol Chem. 2024 Aug 20:107701. doi: 10.1016/j.jbc.2024.107701. Online ahead of print 

Please also see our publication site.

Members

Members in the Virus Research Section are here.

【Professional Staffs】

Tomohiro Sawa, PhD. (Professor)
Hiroyasu Tsutsuki, PhD. (Lecturer)
Katsuhiko Ono, PhD. (Assistant Professor)

Toshio Kasamatsu, PhD. (Research Associate)

Toya Toyomoto, PhD. (Research Associate)

【General Staffs】

Eriko Doi (Technical Assistant)

Azizur Rahman (Technical Assistant)

【Students】

Foysal Hossen (D4)

Chunyu Guo (D3)

Heng Zhong (D3)

Rika Fukushima (D3)

Ziyang Zhang (D1)

Jahan Nusrat (M1)

Hina Honda (M1)

Shinji Kitagawa (M1)