Original Article (English)

1. Perpetual Nyame, P., Togami, A., Yoshida, T., Masunaga, T., Begum, M.M., Terasawa, H., Monde, N., Tahara, Y., Tanaka, R., Tanaka, Y., Appiah-Kubi, J., Amesimeku, W.O., Hossain, M.J., Otsuka, M., Yoshimura, K., Ikeda, T., Sawa, T., Satou, Y., Fujita, M., Maeda, Y., Tateishi, H., Monde, K., A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24. J Biol Chem. 2024 Aug 20:107701. doi: 10.1016/j.jbc.2024.107701. Online ahead of print 
2. Hara, Y., Baba, Y., Oda, E., Harada, K., Yamashita, K., Toihata, T., Kosumi, K., Iwatsuki, M., Miyamoto, Y., Tsutsuki, H., Gan, Q., Waters, R.E., Komohara, Y., Sawa, T., Ajani, J.A., Baba, H., Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers. Br J Cancer, 2024 Jul 12. doi: 10.1038/s41416-024-02753-0. Online ahead of print.  
3. Li, X., Toyomoto, T.,  Zhang, T., Guo, C., Lindahl, S., Tsutsuki, H., Xian, M., Sawa, T., Supersulfides suppress type-I and II interferon responses by blocking JAK/STAT signaling in macrophages. International Immunology, dxae040, https://doi.org/10.1093/intimm/dxae040.     
4. Tomida, J., Miyoshi-Akiyama, T., Kutsuna, R., Tsutsuki, H., Sawa, T., Cnockaert, M., Vandamme, P., Kawamura, Y., Proposal of Helicobacter higonensis sp. nov. isolated from a human clinical specimen, and emended description of Helicobacter valdiviensis Collado, 2014. Microbiol Immunol. 2024 Apr 10. doi: 10.1111/1348-0421.13127.  
5. Maeda, Y., Toyoda, M.,  Kuwata, T., Terasawa, H., Tokugawa, U., Monde, K., Sawa, T., Ueno, T., Matsushita, S., Differential Ability of Spike Protein of SARS-CoV-2 Variants to Downregulate ACE2. Int. J. Mol. Sci. 2024, 25(2), 1353; https://doi.org/10.3390/ijms25021353.
6. Lindahl, S., Shieh, M., Zhang, T., Guo, C., Robinson, J.R., Sawa, T., Xian, M., Thioglucose-derived tetrasulfide, a unique polysulfide model compound. Redox Biology, Available online 17 January 2024, 103045, https://doi.org/10.1016/j.redox.2024.103045. 
7. Ikeda-Imafuku, M., Fukuta, T., Chuang, V.T.G., Sawa, T., Maruyama, T., Otagiri, M., Ishida, T.,  Ishima, Y.,  Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways. Pharmaceuticals 2024, 17(1), 128; https://doi.org/10.3390/ph17010128.

Review (English)

1. Tsutsuki, H., Zhang, T., Akaike, T., Sawa, T., Regulation of innate immune and inflammatory responses by supersulfides. International Immunology, dxad057, https://doi.org/10.1093/intimm/dxad057.

Review (Japanese)

1. 津々木 博康  , 張 田力, 澤 智裕, 腸管出血性大腸菌毒素SubABの病原性発現機構に関わるレドックスバイオロジー YAKUGAKU ZASSHI, 2024 年 144 巻 1 号 p. 57-60. https://doi.org/10.1248/yakushi.23-00162-4.

Original Article (English)

1. Islam, W., Tsutsuki, H., Rahman, A., Harada, A., Zhang, T., Ono, K., Islam, R., Hossen, F., Niidome, T., Sawa, T., Fang, J., Styrene Maleic Acid Polymer-Encapsulated Chlorophyll as a Stable Micellar Nanoprobe for Advanced Anticancer Photodynamic Therapy. ACS Appl. Polym. Mater. 2023, 5, 12, 10289–10302, https://doi.org/10.1021/acsapm.3c02042.
2. Maeda, Y.,  Monde, K., Terasawa, H., Tanaka, Y., Sawa, T., Interaction of TSG101 with the PTAP Motif in Distinct Locations of Gag Determines the Incorporation of HTLV-1 Env into the Retroviral Virion. Int. J. Mol. Sci. 2023, 24(22), 16520; https://doi.org/10.3390/ijms242216520 (registering DOI). 
3. Tahara, Y., Fujita, M., Zhang, T., Wang, D., Tateishi, H., Togami, A., Nyame, P., Terasawa, H., Monde, N., Appiah-Kubi, J., Amesimeku, W.O., Alsaadi, D.H.M., Wada, M., Sugimura, K., Gezici, S., Ciftci, H., Karahan, F., Sekeroglu, N., Otsuka, M.,  Sawa, T., Maeda, Y.,  Watanabe, T.,  Monde, K., Turkish Plants, Including Quercetin and Oenothein B, Inhibit the HIV-1 Release and Accelerate Cell Apoptosis. Biol Pharm Bull. . 2023;46(11):1535-1547. doi: 10.1248/bpb.b23-00328.
4. Toyomoto, T., Ono, K., Shiba, T., Momitani, K., Zhang, T., Tsutsuki, H., Ishikawa, T., Hoso, K., Hamada, K., Rahman A., Wen, L., Maeda, Y., Yamamoto, K., Matsuoka, M., Hanaoka, K., Niidome, T., Akaike, T., Sawa, T., Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics. Front. Microbiol., volume 14, 27 October 2023, https://doi.org/10.3389/fmicb.2023.1276447.
5. Xu, W., Kadoya, Y., Sennari, K., Islam, W., Zhang, T., Sawa, T., Akizuki, F., Hirose, H., Futaki, S., Fujiwara, Y., Komohara, Y., Niidome, T., Disulfiram encapsulated in polymer nanoparticles ameliorates thioacetamide-induced liver injury. Journal of Drug Delivery Science and Technology, 88 (2023) 104981, https://doi.org/10.1016/j.jddst.2023.104981.
6. Matsunaga, T.,  Sano, H.,  Takita, K.,  Morita, M.,  Yamanaka, S.,  Ichikawa, T.,  Numakura, T., Ida, T., Jung, M., Ogata, S., Yoon, S., Fujino, N., Kyogoku, Y.,  Sasaki, Y., Koarai, A., Tamada, T., Toyama, A., Nakabayashi, T., Kageyama, L., Kyuwa, S., Inaba, K., Watanabe, S., Nagy, P., Sawa, T., Oshiumi, H., Ichinose, M., Yamada, M., Sugiura, H., Wei, F.Y., Motohashi, H., Akaike, T., Supersulphides provide airway protection in viral and chronic lung diseases.  Nat Commun 14, 4476 (2023). https://doi.org/10.1038/s41467-023-40182-4.
7. Takeda, H., Murakami, S., Liu, Z., Sawa, T., Takahashi, M., Izumi, Y., Bamba, T., Sato, H., Akaike, T., Sekine, H., Motohashi, H., Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop. Redox Biology Volume 65, September 2023, 102834. https://doi.org/10.1016/j.redox.2023.102834.
8. Araki, S., Takata, T., Ono, K., Sawa, T., Kasamatsu, S., Ihara, H., Kumagai, Y., Akaike, T., Watanabe, Y., Tsuchiya, Y.  Cystathionine γ-Lyase Self-Inactivates by Polysulfidation during Cystine Metabolism. Int. J. Mol. Sci. 2023, 24(12), 9982; https://doi.org/10.3390/ijms24129982.
9. Kawamura, Y., Fujimoto, Y., Kutsuna, R., Tomida, J., Yamamoto, K., Miyoshi-Akiyama, T., Okuno, M., Ogura, Y., Matsuoka, M., Kawaguchi, T., Tsutsuki, H., Sawa, T. Helicobacter kumamotonesis sp. nov., isolated from human clinical specimens. Int. J. Syst. Evol. Microbiol. 2023 Mar; 73(3). doi: 10.1099/ijsem.0.005732. 
     
10. Harada, A., Xu, W., Ono, K., Tsutsuki, H., Yahiro, K., Sawa, T., Niidome, T. Modification of silver nanoparticles with cell-binding subunit of bacterial toxin and their antimicrobial activity against intracellular bacteria. ACS Applied Bio Mater., 2023 Mar 27. doi: 10.1021/acsabm.3c00019.

Review (English)

1. Barayeu, U., Sawa, T., Nishida, M., Wei, F-Y., Motohashi, H., Akaike, T., Supersulfide biology and translational medicine for disease control. Br J Pharmacol. 2023 Oct 23. doi: 10.1111/bph.16271. Online ahead of print.
2. Zhang, T., Akaike, T., Sawa, T. Redox Regulation of  Xenobiotics by Reactive Sulfur and Supersulfide Species. Antioxid. Redox. Signal. 2023 Jun 9. doi: 10.1089/ars.2022.0172.

Review (Japanese)

1. 澤 智裕, 張 田力. グルタチオン排出を介したNLRP3インフラマソームの非活性化機構. 臨床免疫・アレルギー科, 80(3): 379-384, 2023.
2. 澤 智裕. 環境カルボニルストレスと生体応答. Medical Science Digest, 49(1): 21-24, 2023.

Original Article (English)

1. Islam, W., Tsutsuki, H., Ono, K., Harada, A., Shinozaki, K., Niidome, T., Fang, J., Sawa, T., Structural Determination of the Nanocomplex of Borate with Styrene–Maleic Acid Copolymer-Conjugated Glucosamine Used as a Multifunctional Anticancer Drug. ACS Appl. Bio Mater. 2022, December 8, https://doi.org/10.1021/acsabm.2c00883.
2. Monde, K., Satou, Y., Goto, M., Uchiyama, Y., Ito, J., Kaitsuka, T., Terasawa, H., Monde, N., Yamaga, S., Matsusako, T.,    Wei, F-Y., Inoue, I.,  Tomizawa, K., Ono, A., Era, T., Sawa, T., Maeda, Y., Movements of Ancient Human Endogenous Retroviruses Detected in SOX2-Expressing Cells. J. Viol. 2022 May 11;96(9):e0035622. DOI: https://doi.org/10.1128/jvi.00356-22.
3. Yamane, T., Kanamori, Y., Sawayama, H., Yano, H., Nita, A., Ohta, Y., Hinokuma, H., Maeda, A., Iwai, A., Matsumoto, T., Shimoda, M.,1 Niimura, M., Usuki, S., Yasuda-Yoshihara, N., Niwa, M., Baba, Y., Ishimoto, T., Komohara, Y., Sawa, T., Hirayama, T., Baba, H., Moroishi1, T., Iron accelerates Fusobacterium nucleatum–induced CCL8 expression in macrophages and is associated with colorectal cancer progression. JCI Insight. 2022;7(21):e156802.https://doi.org/10.1172/jci.insight.156802.
4. Tsutsuki, H., Zhang, T., Yahiro, K., Toyomoto, T., Sawa, T., Non-canonical inflammasome activation analysis in a mouse model of Citrobacter rodentium infection. STAR Protocols 2022, Vol. 3, Issue 4, 101741; https://doi.org/10.1016/j.xpro.2022.101741.
5. Harada, A., Tsutsuki, H., Zhang, T., Yahiro, K., Sawa, T., Niidome, T.,  Controlled Delivery of an Anti-Inflammatory Toxin to Macrophages by Mutagenesis and Nanoparticle Modification. Nanomaterials 2022, 12(13), 2161; https://doi.org/10.3390/nano12132161 (registering DOI).
6. Tsutsuki, H., Zhang, T., Yahiro, K., Ono, K., Fujiwara, Y., Iyoda, S., Wei, F.Y., Monde, K., Seto, K., Ohnishi, M., Oshiumi, H., Akaike, T., Sawa, T., Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection. iScience, 2022, VOLUME 25, ISSUE 4, 104050, DOI:https://doi.org/10.1016/j.isci.2022.104050. 
7. Kasamatsu, S., Tsutsuki, H., Ida, T., Sawa, T., Watanabe, Y., Akaike, T., Ihara, H. Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants. Nitric Oxide, 2022 Jan 13; S1089-8603(22)00012-X. doi: 10.1016/j.niox.2022.01.004. Online ahead of print.
8. Nomoto, D., Baba, Y., Liu, Y., Tsutsuki, H., Okadome, K., Harada, K., Ishimoto, T., Iwatsuki, M., Iwagami, S., Miyamoto, Y., Yoshida, N., Watanabe, M., Moroishi, T., Komohara, Y., Sawa, T., Baba, H., Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway. Cancer Lett. 2022 Jan 13; S0304-3835(22)00022-2. doi: 10.1016/j.canlet.2022.01.014. Online ahead of print. 

Review (English)

1. Islam, W., Niidome, T., Sawa, T., Enhanced Permeability and Retention Effect as a Ubiquitous and Epoch-Making Phenomenon for the Selective Drug Targeting of Solid Tumors. J. Pers. Med. 2022, 12(12), 1964; https://doi.org/10.3390/jpm12121964.
2. Zhang, T., Tsutsuki, H., Li, X., Sawa, T. New insights into the regulatory roles of glutathione in NLRP3-inflammasome-mediated immune and inflammatory responses. The Journal of Biochemistry, mvab158, https://doi.org/10.1093/jb/mvab158. Online ahead of print.
3. Sawa, T., Akaike, T. Viruses: What triggers inflammation in COVID-19? eLife 2022;11:e76231 DOI: 10.7554/eLife.76231.

Original Article (English)

1. Akter, S., Migiyama, Y., Tsutsuki, H., Ono, K., Hamasaki, C., Zhang, T., Miyao, K., Toyomoto, T., Yamamoto, K., Islam, W., Sakagami, T., Matsui, H., Yamaguchi, Y., Sawa, T. Development of potent antipseudomonal β-lactams by means of polycarboxylation of aminopenicillins. Microbiol Immunol. 2021 Jul 12.  doi: 10.1111/1348-0421.12930. 
2. Islam, W., Kimura, S., Islam, R., Harada, A., Ono, K., Fang, J., Niidome, T., Sawa, T., Maeda, H. EPR-Effect Enhancers Strongly Potentiate Tumor-Targeted Delivery of Nanomedicines to Advanced Cancers: Further Extension to Enhancement of the Therapeutic Effect. J Pers Med. 2021 Jun; 11(6): 487.  doi: 10.3390/jpm11060487. PMID: 34071552
3. Ono, K., Kitamura, Y., Zhang, T., Tsutsuki, H., Rahman, A., Ihara, T., Akaike, T., Sawa, T. Cysteine Hydropersulfide Inactivates β-Lactam Antibiotics with Formation of Ring-Opened Carbothioic S-Acids in Bacteria. ACS Chem. Biol.  (2021) Mar 29. doi: 10.1021/acschembio.1c00027. PMID: 33781062
4. Zhang, T., Tsutsuki, H., Islam, W., Ono, K., Takeda, K., Akaike, T., Sawa, T. ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation. Redox Biol., 41:101930 (2021). doi: 10.1016/j.redox.2021.101930. PMID: 33740502
5. Kamo, M., Ito, M., Toma, T.,Gotoh, H., Shimozono, R., Nakagawa, R., Koga, R., Monde, K., Tateishi, H., Misumi, S., Otsuka, M., Fujita, M. Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M. Bioorganic chemistry 107:104627-104627, 2021.
6. Islam, W., Matsumoto, Y., Fang, J., Harada, A., Niidome, T., Ono, K., Tsutsuki, H., Sawa, T., Imamura, T., Sakurai, K., Fukumitsu, N., Yamamoto, H., Maeda, H. Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis. Biomaterials. 269: 120631 (2021). doi: 10.1016/j.biomaterials.2020.120631.Epub 2020 Dec 26.PMID: 3345058

Review (English)

1. Sawa, T., Tanaka, T., Matsunaga, T., Ihara, H., Motohashi, H., Akaike, T. Chemical Biology of Reactive Sulfur Species: Hydrolysis-Driven Equilibrium of polysulfides as a Determinant of Physiological Functions. Antioxid & Redox Signal. 2022 Feb;36(4-6):327-336. doi: 10.1089/ars.2021.0170. Epub 2022 Jan 4.
2. Zhang, T., Tsutsuki, H., Ono, K., Akaike, T., Sawa, T. Antioxidative and anti-inflammatory actions of reactive cysteine persulfides. J. Clin. Biochem. Nutr., 68: 5-8, 2021.

Review (Japanese)

1. 津々木博康, 張田力, 澤智裕. 超硫黄分子の抗炎症作用. 生化学 Vol.93 No.5, doi:10.14952/SEIKAGAKU.2021.930666
2. 澤 智裕. 超硫黄分子による自然炎症の制御と治療展開．実験医学 2021年8月号 Vol.39 No.13,

Original Article (English)

1. Liu, Y., Baba, Y., Ishimoto, T., Tsutsuki, H., Zhang, T., Nomoto, D., Okadome, K., Yamamura, K., Harada, K., Eto, K., Hiyoshi, Y., Iwatsuki, M., Nagai, Y., Iwagami, S., Miyamoto, Y., Yoshida, N., Komohara, Y., Ohmuraya, M., Wang, X., Ajani, JA., Sawa, T., Baba, H. Fusobacterium nucleatum confers chemoresistance by modulating autophagy in oesophageal squamous cell carcinoma. Br J Cancer. 124:963-974 (2020). doi: 10.1038/s41416-020-01198-5. PMID: 33299132
2. Padilla, ST., Niki, T., Furushima, D., Bai, G., Chagan-Yasutan, H., Telan, EF., Tactacan-Abrenica, RJ., Maeda, Y., Solante, R., Hattori, T. Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection. Biomolecules 10 :1495,2020
3. Huang, S.-F., Othman, A., Koshkin, A., Fischer, S., Fischer, D., Zamboni, N., Ono, K., Sawa, T., Ogunshola, O.O. Astrocyte glutathione maintains endothelial barrier stability. Redox Biol., 34: 101576, 2020. 
4. Maeda, Y., Takemura, T., Chikata, T., Kuwata, T., Terasawa, H., Fujimoto, R., Kuse, N., Akahoshi, T., Murakoshi, H., Van Tran, G., Zhang, Y., Pham, C.H., Pham, A.H.Q., Monde, K., Sawa, T., Matsuoka, S., Nguyen, T.V., Nguyen, K.V., Hasebe, F., Yamashiro, T., Takiguchi, M. Existence of replication-competent minor variants with different coreceptor usage in plasma from HIV-1-infected individuals. J. Virol., 94: e00193-20, 2020. 
5. Harada, A., Tsutsuki, H., Zhang, T., Lee, R., Yahiro, K., Sawa, T., Niidome, T. Preparation of biodegradable PLGA-nanoparticles used for pH-sensitive intracellular delivery of an anti-inflammatory bacterial toxin to macrophages. Chem. Pharm. Bull., 68: 363-368, 2020. 
6. Tsutsuki, H., Kasamatsu, S., Kunieda, K., Ida, T., Sawa, T., Sasakawa, N., Akaike, T., Ihara, H. 8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells. Biochem Biophys Res Commun. 2020 May 21; 526(1): 225-230. doi: 10.1016/j.bbrc.2020.03.045. Epub 2020 Mar 20.
7. Tsutsuki, H., Zhang, T., Harada, A., Rahman, A., Ono, K., Yahiro, K., Niidome, T., Sawa, T. Involvement of protein disulfide isomerase in subtilase cytotoxin-induced cell death in HeLa cells. Biochem Biophys Res Commun. 2020 May 14; 525(4): 1068-1073. doi: 10.1016/j.bbrc.2020.03.008.  Epub 2020 Mar 14.

Review (English)

1. Tsutsuki, H., Ogura, K., Moss, J., Yahiro, K. Host response to the subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli. Microbiol Immunol. 64:657-665 (2020). doi: 10.1111/1348-0421.12841. Epub 2020 Sep 29. PMID: 32902863
2. Sawa, T., Motohashi, H., Ihara, H., Akaike,T. Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides. Biomolecules. 10(9): 1245, 2020. 2020 Aug 27.doi: 10.3390/biom10091245.

Review (Japanese)

1. 澤 智裕. 活性イオウによるToll様受容体シグナルの機能制御．実験医学（増刊） 38 (10): 167-172, 2020

1. Sobuz, SU., Sato, Y., Yoshizawa, T., Karim, F., Ono, K.,Sawa, T., Miyamoto, Y., Oka,M., Yamagata, K..SIRT7 regulates the nuclear export of NF-κB p65 by deacetylating Ran. Biophys Acta Mol Cell Res. 1866(9):1355-1367.2019. doi: 10.1016/j.bbamcr.2019.05.001.
2. Zhang, T. Fang, J., Tsutsuki, H., Ono, K., Islam, W., Sawa, T., Synthesis of Pegylated Manganese Protoporphyrin as a Catalase Mimic and Its Therapeutic Application to Acetaminophen-Induced Acute Liver Failure. Biol. Pharm. Bull. 42,1-9 (2019)
3. Zhang, T., Ono, K., Tsutsuki, H., Ihara, H., Islam, W., Akaike, T., Sawa, T..Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock. Cell Chem Biol., pii: S2451-9456(19)30037-6, 2019. 
4. Hamid, HA., Tanaka, A., Ida, T., Nishimura, A., Matsunaga, T., Fujii, S., Morita, M., Sawa, T., Fukuto, JM., Nagy, P., Tsutsumi, R., Motohashi, H., Ihara, H., Akaike, T..Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis. Redox Biol., 21: 101096, 2019.
5. Fujii, S., Sawa, T., Motohashi, H., Akaike, T.. Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells. Br. J. Pharmacol.,176(4): 607-615, 2019. 
6. Harada, A., Ichimaru, H., Kawagoe, T., Tsushida, M., Niidome, N., Tsutsuki, H., Sawa, T. Niidome, T. Gold-Treated Silver Nanoparticles Have Enhanced Antimicrobial Activity. Bull. Chem. Soc. Jpn.  92(2): 297–301, 2019. doi:10.1246/bcsj.20180232 
7. 澤 智裕、冬眠・休眠とイオウ代謝(特集 エレクトロンバイオダイナミクスが支える生命の生存戦略),細胞7月号,51(8):21-24.2019

1. Masuda, K., Tsutsuki, H., Kasamatsu, S., Ida, T., Takata, T., Sugiura, K., Nishida, M., Watanabe, Y., Sawa, T., Akaike, T. and Ihara, H. Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons. Biochem. Biophys. Res. Commun., 495: 2165, 2018. 
2. Kyaw, K., Motoyama, N., Ichimura, H., Arada, A., Morimura, S., Ono, K., Tsutsuki, H., Sawa, T., Miyazawa, Y., Mizoguchi, D., Niidome, T. A simple PLGA-AgNPL film for antibiofilm formation by contact bactericidal activity. Chem. Lett., 47: 308-310, 2018. 
3. Yahiro K, Nagasawa S, Ichimura K, Takeuchi H, Ogura K, Tsutsuki H, Shimizu T, Iyoda K, Ohnishi M, Iwase H, Moss J, Noda M. Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues. Cell Death Discov.4:22, 2018. 
4. Fukuda, M., Yoshizawa, T., Karim, Md. F., Sobuz, S. U., Korogi, W., Kobayasi, D., Okanishi, H., Tasaki, M., Ono, K., Sawa, T., Sato, Y., Chirifu, J., Masuda, T., Nakamura, T., Tanoue, H., Nakashima, K., Kobashigawa, Y., Morioka, H., Bober, E., Ohtsuki, S., Yamagata, Y., Ando, Y., Oike, Y., Araki, N., Takeda, S., Mizuta, H., Yamagata, K. SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix. Nature Commun., 9: 2833, 2018. 
5. Ichimaru, H., Harada, A., Yoshimoto, S., Miyazawa, Y., Mizoguchi, D., Kyaw, K., Ono, K., Tsutsuki, H., Sawa, T., Niidome, T. Gold coaring of silver nanoparticles for enhanced dispersion stability and efficient antimicrobial activity against intracellular bacteria. Langmuir, 34: 10413-10418, 2018
6. Khan, S., Fujii, S., Matsunaga, T., Nishimura, A., Ono, K., Ida, T., Ahmed, K.A., Okamoto, T., Tsutsuki, H., Sawa, T., Akaike, T.Reactive persulfides from Salmonella Typhimurium downregulate autophagy-mediated innate immunity in macrophages by inhibiting electrophilic signaling. Cell Chem. Biol., 25(11): 1403-1413.e4., 2018. 
7. Sawa, T., Ono, K., Tsutsuki, H., Zhang, T., Ida, T., Nishida, M., Akaike, T. Reactive cysteine persulphides: occurrence, biosynthesis, antioxidant activity, methodologies, and bacterial persulphide signalling. Adv Microb Physiol., 72: 1-28, 2018. 
8. 澤 智裕、赤池孝章．活性イオウによる生体防御応答、エネルギー代謝と寿命制御．実験医学（増刊）, 36: 17-23, 2018． 
9. 津々木博康、澤 智裕、居原 秀．ニトロ化・S-グアニル化．生体の科学（特集 タンパク質・核酸の分子修飾）, 69: 450-451, 2018.

1. Ono, K., Jung, M., Zhang, T., Tsutsuki, H., Sezaki, H., Ihara, H., Wei, FY., Tomizawa, K., Akaike, T., Sawa, T. Synthesis of L-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome. Free Radic. Biol. Med., 2017, Feb. 9.
2. Kyaw, K., Harada, A., Ichimaru, H., Kawagoe, T., Yahiro, K., Morimura, S., Ono, K., Tsutsuki, H., Sawa, T., Niidome, T. Silver Nanoparticles as Potential Antibiofilm Agents Against Human Pathogenic Bacteria. Chemistry Letters. 2017 Feb. 1.
3. Kunikata, H., Ida, T., Sato, K., Aizawl, N., Sawa, T., Tawarayama, H., Murayama, N., Fujii, S., Akaike, T., Nakagawa, T. Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors. Scientific Reports. 2017, 7: 41984
4. Ihara, H., Kitamura, A., Kasamatsu, S., Ida, T., Kakihana, Y., Tsutsuki, H., Sawa, T., Watanabe, Y., Akaike, T. Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation. Biochem J (2017) 474 (7): 1149–1162.
5. Takahashi, N., Wei, F., Watanabe, S., Ohuchi, Y., Fujimura, A., Kaitsuka, T., Sawa, T., Nakayama, H., Akaike, T. and Tomizawa, K. Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion. Nucleic Acids Res., 45: 435-445, 2017. 
6. Ihara, H., Kasamatsu, S., Kitamura, A., Nishimura, A., Tsutsuki, H., Ida, T., Ishizaki, K., Toyama, T.,Yoshida, E., Abdul Hmid H., Jung, M., Matsunaga, T., Fujii, S., Sawa, T., Nishida, M.,Kumagai, Y., and Akaike, T. Exposure to electrophiles impairs reactive persulfide-dependent redox signaling in neuronal cells. Chem. Res. Toxicol., 30: 1673-1684, 2017. 
7. Hoshino, M., Kaneko, K., Miyamoto, Y., Yoshimura, K., Suzuki, D., Akaike, T., Sawa, T., Ida, T., Fujii, S., Ihara, H., Tanaka, J., Tsukuura, R., Chikazu, D., Mishima, K., Baba, K., and Kamijo, R. 8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage. Free Radic. Biol. Med., 110: 63-71, 2017. 
8. Akaike, T., Ida, T., Wei, F.Y., Nishida, M., Matsunaga, T., Alam, M., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Sawa, T., Ihara, H., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S., Nagy, P., Feelisch, M., Fukuto, J.M., Motohashi, H. and Kumagai, Y. Cysteinyl-tRNA synthetase governs protein polysulfidation and mitochondrial bioenergetics. Nature Commun., 8: 1177, 2017. 
9. Tomida, J., Morita, Y., Shibayama, K., Kikuchi, K., Sawa, T., Akaike, T. and Kawamura, Y. Diversity and microevolution of CRISPR loci in Helicobacter cinaedi. PLoS One, 12: e0186241, 2017. 
10. Sawa, T. Oxidative stress regulation by reactive cysteine persulfides in inflammation. In: Chronic Inflammation: Elucidation and Control of the Mechanisms (K. Takatsu and M. Miyasaka eds), Springer, Tokyo, pp309-316, 2016. 
11. Sawa, T., Kumagai, Y. and Akaike, T.  Regulation of redox signaling by a nitrated nucleotide and reactive cysteine persulfides. In: Nitric Oxide: Biology and Pathology Third Edition (L. J. Ignarro, B. A. Freeman eds), Academic Press, London, pp231-234, 2017. 
12. Ikeda, M, Ishima, Y., Shibata, A., Chuang, VTG., Sawa, T., Ihara, H., Watanabe, H., Xian, M., Ouchi, Y., Shimizu, T., Ando, H., Ukawa, M., Ishida, T., Akaike, T., Otagiri, M., Maruyama, T. Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach. Anal Chim Acta, 969: 18-25. 2017 

1. Ahmed, KA., Zhang, T., Ono, K., Tsutsuki, H., Ida, T., Akashi, S., Miyata, K., Oike, Y., Akaike, T., Sawa, T. Synthesis and Characterization of 8-Nitroguanosine 3',5'-Cyclic Monophosphorothioate Rp-isomer as a Potent Inhibitor of Protein Kinase G1α. Biol Pharm Bull. 2016 Dec 16.
2. Jung, M., Kasamatsu, S., Matsunaga, T., Akashi, S., Nishimura, A., Ono, K., Morita, M., Hamid, HA., Fujii, S., Kitamura, H., Sawa, T., Ida, T., Motohashi, H., Akaike, T. Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1. Biochem Biophys Res Commun. 2016 Nov 11; 480(2): 180-186. 
3. Takahashi, N., Wei, FY., Watanabe, S., Hirayama, M., Ohuchi, Y., Fujimura, A., Kaitsuka, T., Ishii, I., Sawa, T., Nakayama, H., Akaike, T., Tomizawa, K. Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion. Nucl. Acids Res. 2016 Aug 27. pii: gkw745.
4. Tsutsuki, H., Jung, M., Zhang, T., Ono, K., Ida T., Kunieda, K., Ihara, H., Akaike, T., Sawa, T. Endogenous occurrence of protein S-guanylation in Escherichia coli: Target identification and genetic regulation. Biochem Biophys Res Commun. 2016 Jul 26. pii: S0006-291X(16)31232-3. 
5. Yugami, M., Odagiri, H., Endo, M., Tsutsuki, H., Fujii, S., Kadomatsu, T., Masuda, T., Miyata, K., Terada, K., Tanoue, H., Ito, H., Morinaga, J., Horiguchi, H., Sugizaki, T., Akaike, T., Gotoh, T., Takai, T., Sawa, T., Mizuta, H., Oike, Y. Mice deficient in Angptl2 show increased susceptibility to bacterial infection due to attenuated macrophage activity. J Biol Chem. 2016 Jul 11. pii: jbc.M116.720870. 
6. Kawamura, Y., Tomida, J., Miyoshi-Akiyama, T., Okamoto, T., Narita, M., Hashimoto, K., Cnockaert, M., Vandamme, P., Morita, Y., Sawa, T., Akaike, T. Proposal of Helicobacter canicola sp. nov., previously identified as Helicobacter cinaedi, isolated from canines. Syst Appl Microbiol. 2016 Jun 25. pii: S0723-2020(16)30049-2. 
7. 井田智章, 松永哲郎, 藤井重元, 澤智裕, 赤池孝章. 活性イオウ含有分子の再発見とその生物活性 日本薬理学雑誌 147(5): 278 -284 2016 
8. Fujii, S., Sawa, T., Nishida, M., Ihara, H., Ida, T., Motohashi, H., Akaike, T. Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides. Arch Biochem Biophys. 595: 140-6.2016 Apr 1. 
9. Hattori, H., Tsutsuki, H., Nakazawa, M., Ueda, M., Ihara, H., Sakamoto, T. Naringin lauroyl ester inhibits lipopolysaccharide-induced activation of nuclear factor κB signaling in macrophages. Biosci Biotechnol Biochem, 11: 1-7, 2016. 
10. Akashi, S., Ahmed, KA., Sawa, T., Ono, K., Tsutsuki, H., Burgoyne, J., Ida, T., Horio, E., Prysyazhna, O., Oike, Y., Rahaman, M., Eaton, P., Fujii, S., Akaike, T. Persistent Activation of cGMP-dependent Protein Kinase by a Nitrated Cyclic Nucleotide Via Site-specific Protein S-Guanylation. Biochemistry, 9; 55(5): 751-61, 2016.
11. Tsutsuki, H., Yahiro, K., Ogura, K., Ichimura, K., Iyoda, S., Ohnishi, M., Nagasawa, S., Seto, K., Moss, J., Noda, M. Subtilase cytotoxin produced by locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli induces stress granule formation. Cell Microbiol. 2016 Jul; 18(7): 1024-40. 
12. Sawa, T. Oxidative stress regulation by reactive cysteine persulfides in inflammation. In: Chronic Inflammation: Elucidation and Control of the Mechanisms (K. Takatsu and M. Miyasaka eds), Springer, Tokyo, pp309-316, 2016.

1. Kikugawa, M., Tsutsuki, H., Ida, T., Nakajima, H., Ihara, H., Sakamoto, T. Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-βaggregation. Biosci Biotechnol Biochem, 80(3): 547-53, 2016.
2. Kunieda, K., Tsutsuki, H., Ida, T., Kishimoto, Y., Kasamatsu, S., Sawa, T., Goshima, N., Itakura, M., Takahashi, M., Akaike, T., Ihara, H. 8-Nitro-cGMP enhances SNARE complex formation through S-guanylation of Cys90 in SNAP25. ACS Chem Neurosci, 21; 6(10): 1715-25, 2015 Oct.
3. Honda, K., Yamada, N., Yoshida, R., Ihara, H., Sawa, T., Akaike, T., Iwai, S. 8-Mercapto-Cyclic GMP Mediates Hydrogen Sulfide-Induced Stomatal Closure in Arabidopsis. Plant Cell Physiol, 56(8): 1481-9, 2015 Aug.
4. Shinkai, Y., Abiko, Y., Ida, T., Miura, T., Kakehashi, H., Ishii, I., Nishida, M., Sawa, T., Akaike, T., Kumagai, Y. Reactive Sulfur Species-Mediated Activation of the Keap1–Nrf2 Pathway by 1,2-Napthoquinone through Sulfenic Acids Formation under Oxidative Stress. Chem Res Toxicol, 18; 28(5):838–847, 2015.
5. Maeda, Y., Terasawa, H., Tanaka, Y., Mitsuura, C., Nakashima, K., Yusa, K., Harada, S. Separate cellular localizations of human T-tropic virus 1 (HTLV-1) Env and glucose transporter 1 (GLUT1) are required for HTLV-1-mediated fusion and infection. J Virol, 89: 502-511, 2015.
6. 津々木博康、小野勝彦、澤 智裕．細菌の硫化水素・RSSの代謝シグナル制御．細胞工学 34: 392-395, 2015
7. 河村好章、富田純子、岡本竜哉、澤 智裕、赤池孝章. H.cinaediと敗血症臨床と微生物 42: 177-182, 2015

1. Aoi, J., Endo, M., Kadomatsu, T., Miyata, K., Ogata, A., Horiguchi, H., Odagiri, H., Masuda, T., Fukushima, S., Jinnin, M., Hirakawa, S., Sawa, T., Akaike, T., Ihn, H. and Oike, Y. Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress. Mol. Cancer Res., 12: 239-249, 2014.
2. Rahaman, Md. M.,* Sawa, T.,* Ahtesham, A. K., Khan, S., Inoue, H., Irie, A., Fujii, S., and Akaike, T. S-Guanylation proteomics for redox-based mitochondrial signaling.Antioxid. Redox Signal., 20: 295-307, 2014. (*equal contribution)
3. Kasamatsu, S., Watanabe, Y., Sawa, T., Akaike, T. and Ihara, H. Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons. Biochem. J., 459: 251-263, 2014.
4. Yoshizawa, T., Karim, Md. F., Sato, Y., Senokuchi, T., Miyata, K., Fukuda, T., Go, C., Tasaki, M., Uchimura, K., Kadomatsu, T., Tian, Z., Smolka, C., Sawa, T., Kakeya, M., Tomizawa, K., Ando, Y., Araki, E., Akaike, T., Braun, T., Oike, Y., Bober, E., and Yamagata, K. SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. Cell Metab., 19: 712-721, 2014.
5. Khan, S., Rahman, H. N. A., Okamoto, T., Matsunaga, T., Fujiwara, Y., Sawa, T., Yoshitake, J., Ono, K., Ahmed, K. A., Rahaman, Md. M., Oyama, K., Takeya, M., Ida, T., Kitamura, Y., Fujii, S., and Akaike, T. Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses. Sci. Rep., 4: 4680, 2014.
6. Ida, T., * Sawa, T.,* Ihara, H.,* Tsuchiya, Y., Watanabe, Y., Kumagai, Y., Suematsu, M., Motohashi, H., Fujii, S., Matsunaga, T., Yamamoto, M., Ono, K., Devarie-Baez, N. O., Xian, M., Fukuto, J. M., and Akaike, T. Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. Proc. Natl. Acad. Sci. USA, 111: 7606-7611, 2014. (*equal contribution)
7. Ono, K., Akaike T,., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., Fukuto, J. The redox chemistry and chemical biology of H2S, hydropersulfides and derivaed species: implications to their possible biological activity and utility. Free Radic. Biol. Med., http://dx.doi.org/10.1016/j.freeradbiomed.2014.09.007.
8. Maeda, Y., Terasawa, H., Nakano, Y., Monde, K., Yusa, K., Oka, S., Takiguchi, M., Harada, S. V3-independent competitive resistance of a dual-X4 HIV-1 to the CXCR4 inhibitor. AMD3100. Plos One e89515, 2014.
9. Nakano, Y., Monde, K., Terasawa, H., Yuan, Y., Yusa, K., Harada, S., Maeda, Y. Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1. Virology 452-453: 117-124, 2014.
10. 井田智章、赤池孝章、澤 智裕、藤井重元．活性酸素と炎症．感染・炎症・免疫， 44: 16-21, 2014.